High-volume pre-dilution on-line hemodiafiltration is the adequate blood purification method from the viewpoint of amino acid nutrition

Abstract Background We compared amino acid leakage among high-volume pre-dilution on-line hemodiafiltration (Pre O-HDF), hemodialysis (HD), and post-dilution (Post O-HDF). Subjects methods The subjects were 9 patients. For HD, the total dialysate flow rate was established as 500 mL/min. Pre O-HDF, it 600 mL/min, under a replacement fluid volume of 90 L. Post 10 In both procedures, duration treatment 4 h, blood 200 leakages acid, non-essential essential clear spaces (CSs), ? 2 -microglobulin (? -MG) reduction rate, Kt/V for urea, albumin three procedures. Results Amino after O-HDF significantly lower than HD O-HDF. CSs -MG urea not different. Albumin below detection limit (< 1 g) in Conclusion Under conditions we performed this time, reduces comparison with High-volume is therapeutic mode that suppresses leakage.